TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance
Abstract Background TetR-family transcriptional regulators (TFTRs) are DNA binding factors that regulate gene expression in bacteria.Well-studied TFTRs, such as AcrR, which regulates efflux pump expression, are usually encoded alongside target operons.Recently, it has emerged that there are many TFTRs which act as global multi-target regulators.Our